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    Our international network, passionate team of experts and extensive industry knowledge is what sets us apart.

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    Seth Flowerman
    President and CEO

AquaLOX®

Deliver Joint Health in Formulations Where Taste Matters
AquaLOX-Logo

OVERVIEW

AquaLOX® is a water-soluble, taste neutral version of PLT’s Boswellia Serrata extract 5-LOXIN®. It allows you to offer joint health in taste-sensitive formulations such as chewables, gummies, stick-packs, shots and more.

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40mg

The recommended dose for AquaLOX is much lower than many conventional joint health ingredients.

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5-LOXIN

AquaLOX is the water-soluble version of one of the world’s best-selling joint health ingredients.

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8 Studies

AquaLOX is supported by 8 preclinical and clinical studies.

FEATURES & BENEFITS

 

Clinically studied

Neutral taste

Low dosage

Vegan suitable

Water-soluble

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CERTIFICATIONS

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GLUTEN-FREE

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NON-GMO

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HALAL

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KOSHER

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ORGANIC

A Patented, Water-Soluble Boswellia serrata extract

The starting point for AquaLOX is Boswellia serrata. Boswellic acids are natural, selective 5-lipoxygenase inhibitors. 3-O-acetyl-11-keto-ß-boswellic acid or “AKBA” is the most active.

Boswellia serrata

Sourced from the forests of India, Boswellia has been used in Ayurvedic medicine for thousands of years.

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Generational harvesting

Boswellia serrata trees are handed down in Indian families as a source of wealth.

Rhodiola rosea

Rhodiola rosea is a plant native to remote Arctic climates in Asia, Europe and North America.

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Exciting Phytochemistry

The root of the plant contains around 140 chemical compounds including phenols, rosavin, rosarin, salidroside and more.

Detail 1

Kale chips cold-pressed put a bird on it mumblecore kogi brooklyn farm-to-table blue bottle yuccie authentic kombucha migas. Literally tilde tacos paleo.

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Detail 2

Kale chips cold-pressed put a bird on it mumblecore kogi brooklyn farm-to-table blue bottle yuccie authentic kombucha migas. Literally tilde tacos paleo.

RESEARCH

Research that builds trust with consumers.

AquaLOX precursor, 5-LOXIN, is a novel Boswellia serrata extract enriched with 30% 3-O-acetyl-11-keto-beta-boswellic acid (AKBA), which exhibits potential anti-inflammatory properties by inhibiting the 5-lipoxygenase enzyme. 5-LOXIN has been the subject of 13 pre-clinical studies and 2 human clinical trials. One of the key features of 5-LOXIN in any formulation is the clinical work that has demonstrated efficacy starting at 7 days – at a significantly lower dose than other joint health ingredients. This fast efficacy and low dose allow 5-LOXIN to compete with non-natural or over-the-counter solutions.


Beyond improving joint comfort and flexibility, 5-LOXIN also positively impacts biological markers associated with joint health and inflammation, including TNFa, CRP, and IL-6. It was also shown to significantly inhibit matrix metalloproteinase (MMP-3), an enzyme that breaks down cartilage, collagen and connective tissues.

 

Pharmacokinetic Study Shows AquaLOX Matches 5-LOXIN

In an RDBC crossover clinical trial, healthy adults took either 40 mg AquaLOX (31.2 mg AKBA) or 100 mg 5-LOXIN (30 mg AKBA) in a random order on separate occasions. The AUC0-∞ (Area under the curve) results showed that similar amounts of total AKBA were absorbed with each product. This demonstrated that the new product form was a highly efficient way of delivering the primary active ingredient.

CLINICAL HIGHLIGHTS

Clinical Study: Pharmacokinetic Study Shows AquaLOX
Matches 5-LOXIN

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Aqualox provides similar benefits to globally bestselling 5-LOXIN for joint comfort. The AUC0-∞ (Area under the curve) results showed that similar amounts of total AKBA were absorbed with each product.

 

GET THE RESULTS

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ACCESS CLINICAL STUDIES

MARKET OPPORTUNITIES

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SPORTS/ACTIVE NUTRITION

AquaLOX is a perfect addition to pre-workout, post-workout and recovery formulations and can be delivered in a range of product forms.

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BONE, JOINT & MUSCLE HEALTH

Joint Health is a huge potential market – but consumers are telling us that they want their joint health solutions to be fast-acting and convenient. AquaLOX can help you deliver new solutions to your customers.

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HEALTHY AGING

Today’s seniors are more active than ever and reach for joint health support to help them maintain their lifestyles. But, even\ younger consumers are aware of the need to support bones and joints to help them get the most out of their years.

APPLICATIONS

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BEVERAGES

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CAPSULES

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CHEWS

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EFFERVESCENTS

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GUMMIES

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POWDERS

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RTDS/SHOTS

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SOFT GELS

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STICK PACKS

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TABLETS

ORIGIN STORY

It Starts with Boswellia

Boswellia serrata, native to India, is one of 19 species of the genus Boswellia. PLT Boswellia-based ingredients are sourced only from select regions of India.

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A Storied Past

The plant resin of the Boswellia tree provides a commercial oil known as frankincense, which has a “woody, spicy and haunting smell.” It is possibly best known through the biblical story of the Three Wise Men, who delivered gifts of gold, frankincense, and myrrh.

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Careful Harvesting

The harvest of Boswellia oleo gum resin occurs through “wounding and healing” of the tree, termed “tapping,” shallow debarking the tree to expose resin glands and stimulate resin production. Harvest is stopped from May through October or November in order to allow a period for tree recovery.

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Exacting Analytics

Boswellia serrata oleo gum resin extracts are evaluated for unique characteristic features. Laila Nutraceuticals has developed an identification method using fingerprint profiles and high-performance thin-layer chromatography (HPTLC) and high-performance liquid chromatography (HPLC).

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State-of-the-Art Processing

Laila Nutraceuticals facilities maintain third-party Good Manufacturing Practices (GMP) certification from NSF International. The NSF certification includes compliance to the U.S. FDA Food Safety Modernization Act (FSMA) and cGMP 21 CFR 117 + 21 CFR 111.

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QUALITY

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From Harvest to Finished Ingredient


The starting point for 5-LOXIN – Boswellia serrata – is a plant that produces Indian frankincense. It is also known as Indian olibanum, Salai guggul, and Sallaki in Sanskrit. The plant is native to much of India and the Punjab region that extends into Pakistan. In partnership with Laila, PLT is committed to the safety and fair treatment of the people who harvest 5-LOXIN. We want to support the long-term health and well-being of the tribal culture and the natural environment upon which it relies.

Every batch of the 5-LOXIN harvest is assigned a specific batch number, and each batch of finished product is traced to a specific region and set of trees. 5-LOXIN is tested and must comply with predefined specifications for different parameters at different stages of product manufacturing – from raw materials to finished product. Quality is monitored by a multi-disciplinary organization with dedicated departments for taxonomy (botanical Identification), raw material analysis, chemical analysis, microbiology, and more.

SUSTAINABILITY

Understanding the Difference Makes the Difference


During the fourth quarter of 2021, PLT Health Solutions announced the commencement of a third-party sustainability audit program on Boswellia serrata trees, which serve as the raw material source for some of our most important ingredients. The audit of this India resource was conducted by renowned botanical research consultancy Botanical Liaisons, LLC, and was undertaken to help the nutraceutical industry and non-governmental agencies around the world understand what we and our ingredient innovation partner Laila Nutraceuticals have known for many years: proper stewardship of natural resources and social responsibility toward the communities that support our work are both the right thing to do and good business.


The audit program was a step in PLT’s campaign to document the sustainability of the tree resource. PLT’s Chairman, Paul Flowerman, made field trips to the key production areas in 2018 and 2019 to observe and document the variety of tree populations, methods of natural and forced propagation and the status of the tribal groups involved in the care of the trees and resin production.

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A third audit program was based on a broad range of environmental, cultural and economic parameters. In March 2022 Botanical Liaisons reported to PLT its preliminary conclusions, which included this statement: “It is clear from the information collected from the stakeholders that [sustainability] is supported. Boswellia serrata has several sustainability advantages that prevent over-harvesting of PLT-sourced Boswellia compared to other sources and species of Boswellia.” The report recommended a series of next steps to further evaluate and promote sustainability. 


Subsequently, four important additional developments have added considerable strength to the Boswellia serrata sustainability story:

  1. Authoritative tree survey data from Madhya Pradesh quantified the robustness and sufficiency of the tree resource to provide present and future resin requirements.
  2. CITES (Convention on International Trade in Endangered Species of Wild Fauna and Flora) determined during its November 2022 meeting (COP 19 in Panama City) that no Boswellia species would get added to the CITES Appendix lists. The health of Boswellia serrata, the only species of commercial importance for PLT, was documented, including information about the replenishment of the resource.
  3. AHPA (American Herbal Products Association) convened an expert panel, which has drafted a brochure entitled, “Good Stewardship Harvesting of Boswellia (Boswellia Serrata).” This is a definitive presentation of current best practices.
  4. An important study modeling the impact of significant climate change by 2050 on Boswellia serrata resources predicted that almost all of Madhya Pradesh, the source of 90+% of commercial resin, will remain conducive for a healthy tree population.

These initiatives represent the type of work we do with our PLT360™ initiative. Introduced in 2015, our PLT360 initiative is a business-wide commitment by PLT Health Solutions to develop ingredients that our customers can be confident and proud to supply to their own customers – knowing that these ingredients are safe, of high quality, efficacious and harvested and manufactured sustainably. PLT360 examines every business decision and business process we undertake to be transparent with our operations, build trust with the health & well-being community and, together with them, support healthier, happier lives for the consumers we serve. 

INSIGHTS

PLT Mobility Solutions AquaLOX graphic

PLT Mobility Solutions

At PLT, we are working on the concept of Mobility Solutions - making these solutions available for people of all ages and walks of life. We’re thinking about athletes who want to perform better and recover faster. We’re thinking about people who have physically demanding jobs who don’t want to or can’t take a day off from work. We’re thinking about anyone who has an active lifestyle who wants to embrace it despite the rigors. And yes, we’re thinking about the global aging population.

PLT Health Solutions’ leading portfolio of mobility support ingredients – based on more than a decade of ongoing research – has been developed to help you deliver innovative products that can capture the attention and the trust of consumers. All of our ingredients are backed by multiple clinical studies – and offer rapid improvements from a low dose - in just about any delivery system you can imagine.

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“AquaLOX is an example of the continuing innovation that PLT Health Solutions offers the market in the joint health support space.”

Seth Flowerman, President & CEO, PLT Health Solutions

RESOURCES

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AquaLOX® Product Sheet
March 20, 2020

Behind every ingredient solution is an even better story, download the product sheet to learn more.

Industry NewsSales Collateral
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PLT Launches Water-Soluble Form of Industry-Leading 5-LOXIN® Joint Health Ingredient
March 31, 2016
Pleasant taste-profile and solubility of AQUALOX broadens range of applications to chews, gummies, stick-packs, shots and more
Industry NewsPress Releases
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