Polar lipids from wheat extract oil improve skin damages induced by aging: Evidence from a randomized, placebo-controlled clinical trial in women and an ex vivo study on human skin explant

Citation: Boisnic S, Keophiphath M, Serandour AL, et al. Polar lipids from wheat extract oil improve skin damages induced by aging: Evidence from a randomized, placebo-controlled clinical trial in women and an ex vivo study on human skin explant. J Cosmet Dermatol. 2019;18(6):2027‐2036. doi:10.1111/jocd.12967

Abstract: Researchers investigated anti-aging effects and benefits for the skin of ceratiq in 64 healthy women, aged from 45 to 60 years. The study lasted 20 weeks, including 12 weeks of oral supplementation with ceratiq oil or placebo and 8 weeks of follow-up. Wrinkles in the "crow's-feet" area were evaluated by the Lemperle score. Skin hydration was measured using a corneometer, while roughness and radiance were determined by clinical scoring. Collagen content was quantified in human skin explants exposed to ultraviolet (UV) irradiations and treated with ceratiq or vehicle control. Compared to the placebo group, the Lemperle score was significantly reduced in the ceratiq group between W0 and W8, reaching a clinically significant 1 grade at W12. Facial hydration was significantly improved in the ceratiq group from W0 to W12, whereas leg hydration was significantly increased after 4 weeks and lasted throughout the supplementation period. Skin roughness and radiance were also significantly improved from W0 to W8 in the ceratiq group compared to placebo group. A higher collagen content was measured in the UV-irradiated skin explants treated with ceratiq compared to the untreated ones. These results confirmed the moisturizing effect of ceratiq and, for the first time, revealed its potential anti-aging properties.