Introduction
The novel botanical combination, LI12542F6 (sold commercially as RipFACTOR®, MyoTOR®, and RipForce®) is a clinically researched dietary ingredient for support of muscle building. Preclinical studies show that LI12542F6 (hereafter referred to as RipFACTOR) works via multiple mechanisms of action, including activation of mTOR, catabolic inhibition (20S proteasome), increased mitochondrial metabolism and increased endothelial nitric oxide synthase (eNOS). These activities support blood flow and anabolism required for muscle building and translate to increased muscle mass, strength and endurance among other effects that have been demonstrated in two randomized, double-blind clinical trials.