Sceletium tortuosum (Zembrin®) ameliorates experimentally induced anxiety in healthy volunteers

Citation: Reay J, Wetherell MA, Morton E, Lillis J, Badmaev V. Sceletium tortuosum (Zembrin^® ) ameliorates experimentally induced anxiety in healthy volunteers. Hum Psychopharmacol. 2020;35(6):1-7. doi:10.1002/hup.2753

Abstract:

Objective: To investigate the anxiolytic properties of a standardized extract of Sceletium tortuosum (trademarked-Zembrin^®).

Methods: Two studies utilized a placebo-controlled, double-blind, between-subject experimental design to investigate the effects of a single dose of Sceletium tortuosum (25 mg, Zembrin^® ) on laboratory stress/anxiety responding in 20 young healthy volunteers. To elicit feelings of stress/anxiety, participants completed 20 min of the multitasking framework in study 1 and a 5-min simulated public speaking task in study 2. Study 1 measured subjective experiences of mood at baseline, prestress induction, and poststress induction. Study 2 measured subjective experiences of anxiety and physiological indicators of stress (heart rate [HR] and galvanic skin response) at baseline, prestress induction, during stress induction, and poststress induction.

Results: A series of analysis of covariances (baseline entered as the covariate) revealed no treatment effect in study 1; however, study 2 revealed subjective anxiety levels to be significantly lower in the Zembrin^® group at the prestress induction point and a significant interaction between treatment and time on HR. Taken together, results indicate that a single dose of Zembrin^® can ameliorate laboratory stress/anxiety responding in healthy volunteers.

Conclusion: We provide the first tentative behavioral evidence to support the anxiolytic properties of Sceletium tortuosum (25 mg Zembrin^® ).

Keywords: Sceletium tortuosum; anxiety; anxiolytic; stress; zembrin.