Xanthigen^® Attenuates High-fat Diet-induced Obesity through Down-regulation of PPARγ and Activation of the AMPK Pathway

Xanthigen^® Attenuates High-fat Diet-induced Obesity through Down-regulation of PPARγ and Activation of the AMPK Pathway

Choi, Kyeong-Mi & Jeon, Young & Kim, Wonkyun & Lee, Anna & Kim, Yong-Gil & Lee, Ju & Kang, Young & Jung, Jae-Chul & Lee, Jeongrai & Min, Bokkee & Kwon, Suk & Davis, Barbara & Lee, Mi Kyeong & Yoo, Hwan-Soo.

(2014) FOOD SCIENCE AND BIOTECHNOLOGY. 23. 931-935. 10.1007/s10068-014-0125-1.

Abstract

Xanthigen, a mixture of brown seaweed and pomegranate seed extracts, has weight loss properties and lipid-lowering effects in mice and humans. This study elucidated the Xanthigen mechanism of an anti-obesity activity in high-fat diet (HFD)-fed mice. Xanthigen decreased expression of peroxisome proliferator-activated receptor γ (PPARγ) in the adipose tissue of HFD-fed mice. The serum leptin level and the adipose tissue leptin expression in mice fed HFD plus Xanthigen were significantly decreased, compared to HFD-fed mice. Phosphorylation of AMP- activated protein kinase (AMPK) α and β and acetyl-CoA carboxylase (ACC) in the adipose tissue of HFD plus Xanthigen-fed mice was elevated, and HMG-CoA reductase (HMGCR) expression was decreased. Xanthigen may have an anti-obesity activity by down-regulation of PPARγ and activation of the AMPK pathway.