Vanizem™
Unlock Your Natural Calm

A novel approach to supporting reduced stress, enhanced mood and quality sleep (all at once)

62% of Global Consumers

Interest in cognitive health is huge and growing

100-150 mg/day dose

Demonstrated improvements at an exceptionally low dos

3 Days

Significant improvements in just days from use

≥ 10% total vanilloids

Extract is standardized to exacting standards

	Clinically studied
	Low 100-150 mg/day dose
	Efficacy starting within 3 days*
	Unique mechanism of action
	Standardized to ≥ 10% total vanilloids
	Standardized to ≥ 1.5% 6-paradol
	HLPC-validated bioactives content
	Proprietary microencapsulation system
	Sustainable, cultivated raw materials

features-benefits-grains-of-paradise-vanizem-ingredient-plt-health-solutions

CERTIFICATIONS

CLINICAL SCIENCE

PATENTED

KOSHER

HALAL

NON-GMO

GLUTEN-FREE

A Spice with a Special History

Vanizem is a proprietary selection and extraction of the West African flowering plant Aframomum melegueta (Grains of Paradise) with standardized bioactives. Its seeds have been used as a spice for millennia.

Aframomum Melegueta

Aframomum melegueta is a species in the ginger family, Zingiberaceae, and closely related to cardamom. Melegueta is a Portuguese word that means ‘chili pepper’.

Grains Of Paradise Ingredient Vanizem Circle

A Botanical Native to West Africa.

Ground or whole, Aframomum melegueta seeds are used as a spice and feature prominently in West African cooking. It is considered a food in the USA (ODI) and Europe.

Rhodiola rosea

Rhodiola rosea is a plant native to remote Arctic climates in Asia, Europe and North America.

rhodiolife-rhodiola-1

Exciting Phytochemistry

The root of the plant contains around 140 chemical compounds including phenols, rosavin, rosarin, salidroside and more.

Detail 1

Kale chips cold-pressed put a bird on it mumblecore kogi brooklyn farm-to-table blue bottle yuccie authentic kombucha migas. Literally tilde tacos paleo.

turmeric-curry-moringa-oleifera-ingredient-slendacor

Detail 2

Kale chips cold-pressed put a bird on it mumblecore kogi brooklyn farm-to-table blue bottle yuccie authentic kombucha migas. Literally tilde tacos paleo.

Clinical Support for Enhanced Mood & Improved Sleep

Thirty participants, aged between 40 and 50 years (44% women) were randomized into a placebo-controlled cross-over study to assess the effect of Vanizem at different doses. All participants
were healthy adults experiencing day-to-day stress. At the start of the trial each participant scored greater than 18 points on a modified-Hamilton Anxiety Rating Scale (mHAM-A), which indicated their tendency toward anxious feelings.

Vanizem helps improve mood

Vanizem was found to significantly (p<0.05) improve self-reported perceptions of tension, depression, vigor and total mood disturbance (TMD) score in a dose-dependent manner.

Vanizem Improves Sleep Quality

Supplementation with Vanizem at doses over 100mg was seen to improve sleep quality scores after just 2 doses versus placebo (p<0.05). Vanizem subjects found it easier to get to sleep, had better sleep quality as well as improved morning alertness.

Clinical Study: Clinical Support for Enhanced Mood and Improved Sleep

Thirty participants, aged 40 to 50 years (44% women) were randomized into a placebo-controlled cross-over study featuring different doses of Vanizem versus a placebo. Vanizem was found to significantly (p<0.05) improve self-reported perceptions of tension, depression, vigor and total mood disturbance (TMD) score in a dose-dependent manner. Supplementation with Vanizem at doses over 100mg was seen to improve sleep quality scores after just 2 doses versus placebo (p<0.05).

GET THE RESULTS

MARKET OPPORTUNITIES

COGNITIVE HEALTH

Sleep, stress reduction and mood enhancement are all important aspects of good overall cognitive health. With Vanizem, you can make products for any or all of these categories.

Mood/Stress

Vanizem can help contribute to people’s overall sense of well-being. Stress reduction is increasingly targeted by consumers in every walk of life.

WOMEN'S HEALTH

Increasingly, better sleep and less stress are seen as particularly important in meeting the health needs of women – particularly as they age. Vanizem offers clinically demonstrated sleep and mood benefits.

SLEEP

Want to formulate for better sleep? Vanizem subjects found it easier to get to sleep, had better sleep quality as well as improved morning alertness – after just 2 doses.

APPLICATIONS

CAPSULES

POWDERS

STICK PACKS

TABLETS

CHEWS

╳

ORIGIN STORY & INSIGHTS

A West African Staple with a Storied Past

The journey of Vanizem starts in a region of West African often called the Pepper or Grain Coast because of the importance of Aframomum melegueta – also known as Grains of Paradise - to life, culture and economy of the region

A Spice Common to Diets Around the World

Melegueta pepper is commonly used in the cuisines of West and North Africa, Grains of Paradise becoming more popular in North America due to their use by some well-known celebrity chefs.

Nutra-Ingredients-USA-PLT-adds-Vanizem-to-cognitive-health-platform

Cultivated Starting Points. Trusted Supply.

The Aframomum melegueta used in Vanizem is sourced from well-known, trusted suppliers. The material is cultivated, which helps improve quality control and sustainability.

State-of-the-art Manufacturing

State-of-the-art ManufacturingVanizem is extracted in Nektium Pharma’s state-of-the-art facilities in Lad Palmas, Spain. It features a patent-pending microencapsulation technology that offers improved stability against time and temperature and water dispersibility.

A Unique Mechanism of Action

Vanizem is unique in the cognitive health space, not just because of its exciting benefits, but because of its mechanism of action. It targets the endocannabinoid system, which is a key regulator of stress and emotional responses.

ELDERBERRY-CHART-1024x520

A Standardized, Assured Identity Ingredient

To assure you of the highest quality ingredient available, PLT-supplied Vanizem extract undergoes multiple qualifying tests. Vanizem is made with an ethanolic-extract to preserve actives the botanical actives. It is standardized at 10% of total Vanilloids and 1.5 % of 6-paradol.

The Nektium ID Assessment Program

Nektium’s Quality Assurance team conducts multiple identity tests on every batch of Vanizem, including macroscopic and sensorial analysis, the development of chromatographic profiles and independent DNA barcode analysis. The resulting HPLC ‘fingerprint’ of the Vanizem extract is consistent from batch to batch.

Our international network, passionate team of experts and extensive industry knowledge is what sets us apart.

Vanizem™ Unlock Your Natural Calm

OVERVIEW

VanizemTM is a fast-acting botanical extract that supports positive mood, improves sleep quality and provides effective management of mild day-to-day stress and anxious feelings.

62% of Global Consumers

100-150 mg/day dose

3 Days

≥ 10% total vanilloids

FEATURES & BENEFITS

Clinically studied

Low 100-150 mg/day dose

Efficacy starting within 3 days*

Unique mechanism of action

Standardized to ≥ 10% total vanilloids

Standardized to ≥ 1.5% 6-paradol

HLPC-validated bioactives content

Proprietary microencapsulation system

Sustainable, cultivated raw materials