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    Our international network, passionate team of experts and extensive industry knowledge is what sets us apart.

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    Seth Flowerman
    President and CEO

menatto® Vitamin K2

Bone and heart health for every age
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OVERVIEW

menatto® Vitamin K2 (MK-7) is the world’s premier source of Vitamin K2 – sustainable, clean-label, featuring an unparalleled clinical support package.

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10 Studies

menatto has been in clinical trials on bioavailability, bone health, heart health and more.

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20+ Years

menatto was ‘the original’ Vitamin K2 supplement source – developed in 1997.

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>7 Times

A PK study showed that menatto achieved much higher blood levels of Vitamin K than synthetic Vitamin K1.

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100% Traceable

Made with a vertically-integrated process, menatto is controlled from farm to table.

FEATURES & BENEFITS

 

Ten clinical studies

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Products of fermentation

Proven bioavailability

Fully traceable

Versatile in formulation

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Oil and powder forms

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CERTIFICATIONS

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GLUTEN-FREE

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NON-GMO

Vitamin K2 (MK-7) from a Much-loved Food

menatto Vitamin K2 made via a natural fermentation process using a bacterial strain of Bacillus subtilis isolated from the traditional fermented Japanese food natto. 

Fermented from Natto

Soybeans are transformed into natto by being steamed and then fermented with natto-kin (a type of bacteria). This process produces a special savory taste.

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More Bioavailable

The MK-7 form of vitamin K2 is the most bioavailable form of Vitamin K.

Rhodiola rosea

Rhodiola rosea is a plant native to remote Arctic climates in Asia, Europe and North America.

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Exciting Phytochemistry

The root of the plant contains around 140 chemical compounds including phenols, rosavin, rosarin, salidroside and more.

Detail 1

Kale chips cold-pressed put a bird on it mumblecore kogi brooklyn farm-to-table blue bottle yuccie authentic kombucha migas. Literally tilde tacos paleo.

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Detail 2

Kale chips cold-pressed put a bird on it mumblecore kogi brooklyn farm-to-table blue bottle yuccie authentic kombucha migas. Literally tilde tacos paleo.

 

RESEARCH


menatto Vitamin K2 has been the subject of ten human clinical studies on the actual article of commerce – more than any other Vitamin K2 on the market.

 

Numerous studies have shown that menatto is more efficacious than other forms of Vitamin K in elevating plasma Vitamin K levels.

Post-menopausal woman and bone health

A 3-year, randomized, double-blind, placebo-controlled study of post-menopausal women found that supplementing with low-dose menatto Vitamin K2 helped bind calcium to bones, supporting healthy bone mineral density.* menatto significantly improved vitamin K status compared to placebo and helped support bone mineral density (BMD) and bone strength.*

Knapen MHJ, et al. Osteoporos Int. 2013 Sep;24(9):2499-507.


Bone health for middle-aged men and women

Ninety-four participants with an average age of 52.4 were randomly assigned to take either 180 mcg of menatto per day or placebo for 1 year. They were advised to take two other nutrients — vitamin D and calcium since this trio works together to support bone health.* Researchers followed up at 2, 6, and 12 months and took measurements of bone mineral density at the lumbar spine and the femoral neck. menatto supported bone mineral density in the lumbar spine and supported bone mineral content in the femoral neck, which is an indicator of bone strength.

*Forli L, et al. Transplantation. 2010 Feb 27;89(4):458-64.

 

Calcium metabolism in children

A randomized, double-blind, placebo-controlled study of pre-pubescent children found that menatto vitamin K2 effectively raised blood levels of vitamin K2 compared to placebo, and helped ensure the proper level of carboxylated osteocalcin, a protein that regulates healthy bone formation.

*van Summeren MJH, et al. Br J Nutr. 2009 Oct;102(8):1171-78.

 

Supporting health blood vessel elasticity

A 3-year, randomized, double-blind, placebo-controlled study of healthy post-menopausal women found that three years of supplementation with menatto supported healthy blood vessel elasticity by helping maintain the right type of matrix Gla protein in the blood vessel wall.* This action may support healthy blood flow, contributing to cardiovascular health.

*Knapen MHJ, et al. Thromb Haemost. 2015 May;113(5):1135-44.

***The research cited above was conducted with Vitamin K2 produced by J-Oil Mills, which is currently marketed under the menatto® brand name.  Neither J-Oil Mills nor PLT Health Solutions sponsored or participated in the funding of these studies.

CLINICAL HIGHLIGHTS

Clinical Study: menatto vitamin K2 (MK7) results in higher blood levels than vitamin K1

Menatto single dose more efficacious than vitamin K1 chart and image

In a 4-part pharmacokinetic study on blood levels and stability of Vitamin K sources, taking menatto™ vitamin K2 (MK7) resulted in more stable and higher blood levels of vitamin K (7-8 fold higher) than vitamin K1. In addition, menatto supported the carboxylation of osteocalcin, a protein that helps calcium bind to bone and thus keeps bones strong.

Schurgers LJ, Teunissen KJ, Hamulyák K, Knapen MH, Vik H, Vermeer C. Vitamin K-containing dietary supplements: comparison of synthetic vitamin K1 and natto-derived menaquinone-7. Blood. 2007;109(8):3279-3283. doi:10.1182/blood-2006-08-040709


GET THE RESULTS

Menatto single dose more efficacious than vitamin K1 chart and image

Clinical Study: Post-menopausal women and bone health

Menatto improves circulating cOC over time chart and image

A 3-year, randomized, double-blind, placebo-controlled study of post-menopausal women found that supplementing with low-dose menatto Vitamin K2 helped bind calcium to bones, supporting healthy bone mineral density.* menatto significantly improved vitamin K status compared to placebo and helped support bone mineral density (BMD) and bone strength.
* Knapen MHJ, et al. Osteoporos Int. 2013 Sep;24(9):2499-507.


GET THE RESULTS

Menatto improves circulating cOC over time chart and image
ACCESS CLINICAL STUDIES

MARKET OPPORTUNITIES

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Bone Health

Vitamin K2 has shown to encourage the development of healthy bones in children and the maintenance of healthy bones in adults.

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Cardiovascular Health

Vitamin K2 serves a key role in cardiovascular health through regulation of calcium homeostasis.

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HEALTHY AGING

Affecting both cardiovascular health and bone health, menatto Vitamin K2 is a perfect ingredient for anti-aging formulas.

APPLICATIONS

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CHEWS

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CONFECTIONARY

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EFFERVESCENTS

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GUMMIES

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POWDERS

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RTDS/SHOTS

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SOFT GELS

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STICK PACKS

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TABLETS

ORIGIN STORY

Vitamin K2 from natto

The starting point for menatto is the traditional Japanese food natto. Why? Because it’s the richest food source of Vitamin K2 on the planet. When and how natto originated is open to debate.

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Dating Back to the 11th Century in Japan

In one story, 11th century Japanese soldiers were boiling soybeans and were attacked. The troops retreated – leaving their soybeans behind – and returned several days later. In their absence, the soldiers’ soybeans had fermented naturally, and they found they liked the taste.

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Natto: Made According to Tradition

Natto is made from soybeans, typically natto soybeans. These beans are washed, soaked in water and steamed. The beans are then mixed with the bacterium Bacillus subtilis, known as natto-kin in Japanese. Afterward, it is cooled, then aged in a refrigerator for up to one week.

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Fermented Vitamin K2

Following the fermentation process, Vitamin K2 is extracted using pure sunflower oil and the K2-infused oil undergoes water refining to remove impurities – followed by a deodorization process using distillation. This material is blended with pure sunflower oil.

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Fully Traceable Production

As a vertically integrated company, J-Oil Mills can trace all phases of menatto™ production, from procurement of raw materials to manufacturing to distribution, meeting our customers’ and end consumers’ need for traceability.

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QUALITY

Transparent, Certified Quality

PLT innovation partner J-Oils Mills takes meticulous care to ensure the quality of its products. menatto is manufactured in its own third-party GMP-certified manufacturing plant in Shizuoka, Japan, where we meet or exceed current standards for good manufacturing practices. The facility is also ISO 22000-certified to ensure safe food management. Additionally, menatto has achieved self-affirmed GRAS status in the United States and novel food status in the European Union.

The process for making menatto starts with natto, the traditional fermented Japanese food that is naturally rich in vitamin K (as K2). In fact, natto contains 500 times more vitamin K2(MK-7) than the next-highest food source.

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• Isolation
B. subtilis natto, a probiotic strain of bacteria, is isolated from natto.


• Inoculation
B. subtilis natto is inoculated intoa sterilized plant-based media.


• Fermentation
The B. subtilis natto, goes to work fermenting the plant-based media in a controlled-temperature environment. During the fermentation process, vitamin K2 is produced.

• Extraction
Our K2 is extracted with pure sunflower oil.

• Purification
The K2-infused oil undergoes water refining to remove impurities.

• Deodorization
The odoriferous components of the oil are removed through a unique distillation process, rendering it tasteless and odorless.

Blending
To produce menatto® vitamin K2 MK-7 Oil 1500, the refined, deodorized oil is blended with pure sunflower oil until concentrations facilitate the formulation process, after which it is micro-filtrated.

• Spray-drying
To produce menatto® vitamin K2 MK-7 Powder 1000/2000, the refined, deodorized oil is emulsified with natural excipients, powdered, and then filtrated.

INSIGHTS

Background on Vitamin K

MK-7 from PLT is menaquinone-7, a form of Vitamin K2. PLT MK-7 There are two broad categories of Vitamin K used in supplements. Vitamin K1 (phylloquinone or phytonadione) is the form found in plants, such as leafy green vegetables. Vitamin K2 (menaquinone, such as MK-4 and MK-7) is found in animals and certain fermented foods. Menaquinones naturally have greater bioavailability. At least 50-60% of the circulating Vitamin K in the body is in the form of K2. The MK-7 form of vitamin K2 is the most bioavailable form of Vitamin K. This was established by research done specifically on J-Oil Mills’ MK-7. Human clinical trials with menatto have demonstrated higher bioavailability than MK-4 and more than seven times the bioavailability of vitamin K1, making menatto the most bioavailable vitamin K commercially available. Another study demonstrated that menatto is bioavailable in diverse delivery systems.

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Vitamin K and Vitamin D

When it comes to calcium metabolism, vitamins D and K work together. Both are fat-soluble vitamins that play important roles in the body. Vitamin D promotes the production of vitamin K-dependent proteins, which require vitamin K for carboxylation in order to function properly. Some clinical studies have shown that supplementation with both at the same time improves health outcomes. Consumer products featuring both are increasingly popular in the market – particularly in products targeted to post-menopausal women.


PLT Health Solutions offers one of the most innovative, consumer-friendly Vitamin D solutions on the market today – Earthlight® Whole Food Vitamin D.

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“menatto Vitamin K2 is the most clinically studied Vitamin K2 on the planet today.”

Sid Hulse, Vice President, Product Development, PLT Health Solutions

RESOURCES

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menatto Product Sheet
May 10, 2021
Behind every ingredient solution is an even better story, download the product sheet to learn more.
Industry NewsSales Collateral
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Vitamin K Status in Children Improves Bone Health in New Study
October 23, 2022
A better vitamin K status was associated with more pronounced increase in bone mass in healthy children - yet western populations are likely vitamin K deficient
Industry NewsPress Releases
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Bone Quality in Children may be Compromised by Therapy with Vitamin K-Antagonists
October 22, 2022
PL Thomas and its partner NattoPharma would like to make known a new publication by Avgeri et al. (J Pediatr Hematol Oncol)
Industry NewsPress Releases
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Vitamin K is required to inhibit calcium accumulation in the arteries: New Paper in Thrombosis and Haemostasis
October 2, 2022
A new publication by Schurgers et al., titled Matrix Gla-protein: The calcification inhibitor in need of vitamin K
Industry NewsPress Releases
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Low Vitamin K2 Status is a Risk Factor for Hardening of the Arteries
April 1, 2008
PL Thomas and NattoPharma, Norway, announced significant exposure and discussion of Vitamin K2 and its role in promoting cardiovascular health at the American Society of Nephrology’s Renal Week 2008 in Philadelphia.
Industry NewsPress Releases
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Bone Health – What Now?
September 14, 2022
Vitamin D3 and Calcium may not be the only 'go-to' nutrients for bone health. Growing evidence suggests Vitamin K2 may play an important role in keeping bones strong.
Industry NewsPress Releases
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PLT Health Solutions to Sponsor Vitamin K2 Workshop at SupplySide West
October 9, 2015
PLT Health Solutions proudly announces its sponsorship of the Vitamin K2 Workshop at SupplySide West.
Industry NewsPress Releases
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Low Vitamin K2 Status is a Risk Factor for Hardening of the Arteries – Presented at the American Society of Nephrology Convention
August 28, 2022
PL Thomas and NattoPharma, Norway, announced significant exposure and discussion of Vitamin K2 and its role in promoting cardiovascular health at the American Society of Nephrology’s Renal Week 2008 in Philadelphia.
Industry NewsPress Releases
read more
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PLT Will Market J-Oil Mills’ menatto™ Vitamin K2 (MK-7) in North America
March 30, 2022
The World’s Most Researched Vitamin K2 is the Subject of Ten Human Clinical Trials
Industry NewsPress Releases
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Nutraceutical Business Review: PLT Health verified by non-GMO project 28686E9C-0345-47E1-B5C6-FB030592A87D
November 2nd, 2022
Nutraceutical Business Review: PLT Health verified by non-GMO project
Industry NewsIndustry News
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Nutraceuticals Business Review: “PLT to market J-Oil Mills vitamin K2 ingredient in America” 28686E9C-0345-47E1-B5C6-FB030592A87D
March 30th, 2022
PLT Health Solutions has announced it will market the menatto brand of Vitamin K2 (MK-7) manufactured by Tokyo’s J-Oil Mills in North America for use in consumer products supporting cardiovascular health, bone health, and general health.
Industry NewsIndustry News
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Nutrition Industry Executive: “PLT Will Market J-Oil Mills’ menatto™ Vitamin K2 (MK-7) in North America” 28686E9C-0345-47E1-B5C6-FB030592A87D
May 16th, 2022
PLT Health Solutions, Inc. announced today that it will market menatto brand of Vitamin K2 (MK-7) manufactured by an edible oils producer J-Oil Mills (Tokyo, Japan) in North America for use in consumer products supporting cardiovascular health, bone health, and general health.
Industry NewsIndustry News
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Nutrition Insight: “PLT Health Solutions partners with J-Oil Mill’s for vitamin K2 market expansion” 28686E9C-0345-47E1-B5C6-FB030592A87D
May 16th, 2022
The move aims to expand the vitamin K2 market across the continent, showcasing the menatto brand to target consumer products supporting cardiovascular health, bone health and general health.
Industry NewsIndustry News
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Nutrition Industry Executive: PLT Health Solutions menatto™ Vitamin K2 is Verified Non-GMO by the Non-GMO Project 28686E9C-0345-47E1-B5C6-FB030592A87D
October 31st, 2022
PLT Health Solutions, Inc. announced that it has received non-GMO verification from the Non-GMO Project company for its menatto™ Vitamin K2 (MK-7) ingredient.
Industry NewsIndustry News
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Natural Practitioner: PLT Health Solutions menatto™ Vitamin K2 is Verified Non-GMO by the Non-GMO Project 28686E9C-0345-47E1-B5C6-FB030592A87D
March 31st, 2022
PLT Health Solutions, Inc. announced that it has received non-GMO verification from the Non-GMO Project company for its menatto™ Vitamin K2 (MK-7) ingredient.
Industry NewsIndustry News
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Food Ingredients First: PLT nets non-GMO verification for menatto, building “trust” and boosting vitamin K for vegans 28686E9C-0345-47E1-B5C6-FB030592A87D
November 1st, 2022
PLT Health Solutions has received approval from the Non-GMO Project to sell its menatto brought by Japanese oils producer J-Oil Mills under this label.
Industry NewsIndustry News
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PLT Health Solutions menatto™ Vitamin K2 is Verified Non-GMO by the Non-GMO Project
October 21, 2022
Premium Vitamin K2 (MK-7) is Clinically Studied, Fully Traceable and Clean Label
Industry NewsPress Releases
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