Multiple Pathways to Enhance Endurance, Strength and Muscle Growth

The power of RipFACTOR is its ability to act on your body in a number of different ways related to endurance, strength and muscle growth. Early clinical studies showed that RipRACTOR provides:

• Activation of mTOR – the key regulator of skeletal muscle mass

• Enhanced protein synthesis and muscle cell growth

• Inhibition of protein degradation & muscle breakdown

• Enhanced nitric oxide generation, increasing blood flow and fueling muscle energy and endurance

In two double-blind clinical trials, subjects taking RipFACTOR showed highly significant improvements in muscle endurance, strength, muscle size, and lean body mass compared to placebo. These effects were observed in both resistance-trained healthy men and in untrained men performing bench press, cable pull-down, leg press, and dynamometer (grip strength) tests. Statistically significant improvements are documented after just two weeks and continue to improve throughout the length of the 2-month studies.

The two trials were both 8 weeks long, with subjects evaluated in the gym 3 times per week. However, there are also some important distinctions between the two studies:

• Men in Study 1 were recreationally active and at least familiar with resistance training, whereas those in Study 2 were recreationally active but resistance training-naive. The training protocol was supervised in both studies, but more closely in Study 2 to ensure proper training was followed in this group of resistance-training naïve participants.

• The training protocol for Study 1 involved whole-body training (bench press, leg press, cable pull-down, treadmill, dynamometer), whereas in Study 2, participants were trained only on the measured endpoints (one set of bilateral bench press and leg extension resistance training sessions).

• Study 1 was conducted using RipFACTOR at 650 mg/d (Ultra-Performance dose).  Study 2 used RipFACTOR WD at two doses: 425 mg (Performance dose) and 850 mg/d (Ultra-Performance dose).  Both the 650 mg and 850 mg doses of RipFACTOR and RipFACTOR WD, respectively, contained the same amount of actives (650 mg); the only difference was 200 mg of excipient in the 850 mg dose. The 425 mg dose of WD contained 325 mg of actives and 100 mg of excipient.

Study 1 evaluated the efficacy of RipFactor in improving muscle health. In a randomized, double-blind, placebo-controlled trial, 40 male participants of 18–40 years of age were assigned to receive 650 mg of RipFACTOR (A) or Placebo (P) for 56 days. The primary endpoint was the change from baseline in muscle strength, assessed by 1-RM Bench and Leg presses. Secondary endpoints included muscle endurance, time to exhaustion, muscle size, body composition and free testosterone. Safety was also assessed. 

Results: Significant (P < 0.0001) increases in change from baseline for strength bench and leg presses and grip strength were observed in the A vs. P group beginning at 14 d and continuing throughout the study. Muscle endurance and time to exhaustion were similarly increased by 14 d and continued for the remainder of the study. By day 56, the mid-upper arm circumference was statistically increased in A vs. P  (P < 0.05) in left and right arms.  Secondary endpoints, including muscle endurance, TTE, body composition, and free testosterone, all significantly improved compared to those of the placebo. Serum Cortisol was significantly lower in the treatment group compared to placebo. Lean body mass (the difference between total body weight and body fat weight) increased by 1.44 kg (2.8% improvement) in the RipFACTOR group compared to just 0.03 kg (0.06% improvement) in the placebo group. Total Body Fat decreased by 0.97 kg (5.25% decrease) in the RipFACTOR group and by 0.20 kg (1.15% decrease) in the placebo group. Percent Body Fat decreased by 1.50% in the RipFACTOR group compared with only 0.24% in the placebo group. 

Study 2 evaluated the efficacy of RipFactor WD to improve muscle health ¹. This was a prospective, randomized, double-blind, placebo-controlled study to assess the comparative efficacy and safety of RipFACTOR WD 425 mg/d (Group A, “performance dose”) and RipFACTOR WD 850 mg/d (Group B, “ultra-performance dose”) in comparison with two groups consuming placebo and performing either one set of physical training (Group C) or two sets of training (Group D), respectively. 

Results: 1RM bench press values increased by 37% and 44% in treatment groups A and B, respectively, versus 17% and 24% in placebo groups C and D, respectively, from baseline to the end of the study. Significant improvement in 1RM leg extension values was observed after 14 days of supplementation in treatment groups A and B when compared to placebo group C. A statistically significant increase in 1RM values of leg extension was observed in the treatment groups A and B when compared with both placebo groups C & D (at days 28 and 56). Muscle endurance, measured as the number of reps on bench press, was also different between active and placebo groups (A-C, B-D, and B-D achieved statistical significance). Both free and total testosterone significantly increased when compared to Groups A-C and Groups B-C. Both doses of RipFACTOR improved physical strength in training-naïve subjects as measured by bench press and leg extension. However, 850 mg/d was more efficacious in enhancing the subjects' physical endurance than 425 mg/d.

¹ [No authors listed] The Effects of a Botanical Blend Supplement (LI12542F6) on Muscle Strength and Endurance During Resistance Training - A Randomized, Double Blind, Placebo Controlled Trial. 2018 [Data on file].

Two groups of healthy, regular gym-goers were studied in a gold-standard clinical trial. The trial measured performance in leg & bench press, grip strength, cable pulldown, treadmill and overall body composition – including key biomarkers.

The Cutting Edge of Sports Nutrition

Based on mechanistic, pre-clinical and clinical data, with RipFACTOR, you can tell consumers a compelling story about a 60-day journey to improve physical performance.
That makes RipFACTOR both an experiential ingredient and one that can become a part of their lifestyle – helping you to build strong brands.