Xanthigen®

Clinically Supported Weight Loss & Body Fat Reduction

OVERVIEW

Xanthigen is a best-selling weight management ingredient around the world. It is rich in antioxidants and polyphenols. It offers weight loss, body fat reduction, a decreased waist circumference and an improved blood lipid profile.

600mg

Xanthigen works with a low daily dose.

14.2 lbs Lost

Xanthigen helped study participants lose significant weight in a 6-week study.

#1

Xanthigen is the top-selling weight management ingredient in Korea – and has been for years.

151 Subjects

Xanthigen’s most recent study featured a large number of subjects.

FEATURES & BENEFITS

Loss of 14.2 pounds (6.6 kg) over sixteen weeks

Body fat reduction

Decreased waist circumference

Improved lipid profiles

#1 weight loss ingredient in Korea

Sustainably cultivated

CERTIFICATIONS

VEGAN

GLUTEN-FREE

SOLVENT-FREE

NON-GMO

HALAL

KOSHER

Weight Loss from Sea and Farm

Xanthigen is a proprietary patented combination of brown seaweed extract (BSE) native to the coasts of the Pacific Ocean standardized to ≥ 0.425% fucoxanthin content and pomegranate seed oil (extract rich in punicic acid (≥70%), PA) cultivated throughout the Mediterranean region.

Brown Seaweed

Brown seaweed contains fucoxanthin, an antioxidant that gives the vegetable its color.

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Pomegranate Seed Oil

The word pomegranate is derived from the medieval Latin “Punica granatum,” meaning apple of many grains or seeds.

Rhodiola rosea

Rhodiola rosea is a plant native to remote Arctic climates in Asia, Europe and North America.

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Exciting Phytochemistry

The root of the plant contains around 140 chemical compounds including phenols, rosavin, rosarin, salidroside and more.

Detail 1

Kale chips cold-pressed put a bird on it mumblecore kogi brooklyn farm-to-table blue bottle yuccie authentic kombucha migas. Literally tilde tacos paleo.

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Detail 2

Kale chips cold-pressed put a bird on it mumblecore kogi brooklyn farm-to-table blue bottle yuccie authentic kombucha migas. Literally tilde tacos paleo.

Clinical Efficacy to Support Healthy Weight

Xanthigen is supported by clinical and pre-clinical research that shows efficacy in human subjects and provides an understanding of how Xanthigen works.

• Peer-reviewed, published, double-blind, placebo-controlled clinical trial

• Study subjects consumed a controlled, calorie-reduced diet for 16 weeks along with either 600 mg Xanthigen or a placebo. Participants using Xanthigen daily lost an average of 14.2 pounds (6.6 kg) over sixteen weeks.

• Significant differences in weight loss vs. placebo began at 6 weeks.

• Xanthigen supplementation also resulted in significant body composition improvements including reduced body and liver fat. Though not achieving statistical significance, those in the Xanthigen group lost 4.16 cm (1.6 in) in hip circumference.

• Significant improvements in blood lipids, liver enzymes and blood pressure demonstrate better overall health in subjects consuming Xanthigen.

Developing Messaging within a Regulatory Environment

An EU-based consumer products company was interested in featuring Xanthigen in a cutting-edge weight management product launch. PLT worked with this company to develop a regulatory dossier on this ingredient. We helped them craft their claims and marketing messages combining knowledge of a clinical trial and understanding pending EU claims related to Xanthigen components. The ingredient launched to excellent sales in France and on Amazon in late 2017.

Pathways to Weight Management

Energy metabolism is regulated by many pathways. This redundancy was an important mechanism that helped the body conserve energy during times of less plentiful food supply (think the time of cave men when food availability was uncertain). Today, with calories being abundant, this ancient preservation mechanism is not needed, but is built into our biology. So, excess calories are stored as fat. It is important to consider this when developing weight management ingredients and target multiple pathways to promote effective weight loss.

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Separately, the bioactive compounds in Xanthigen target pathways involved in body weight regulation including adipocyte differentiation, resting energy expenditure and lipid metabolism. Combined in Xanthigen they support weight loss as demonstrated in our clinical trial.

Helping to Develop a Regulatory Portfolio

A South Korea-based contract manufacturer wanted to develop Xanthigen for sales into Korea and potentially other Asian markets. Even though Xanthigen had safety studies and a human clinical trial, to achieve registration of this ingredient in Korea, the company needed additional research to meet the rigorous regulatory requirements, PLT’s Medical & Scientific Affairs team worked with Korean partners to design the necessary trials to complete the registration package. Today, this company has 21 different Xanthigen SKUs in Korea where it is the top selling weight management ingredient.

Clinical Study: Xanthigen Supports Weight Loss & Body Shaping

xanthigen reduced waist circumference chart

Study subjects taking 600 mg Xanthigen daily lost an average of 14.2 pounds (6.6 kg) over sixteen weeks and significant improvements in body composition.

GET THE RESULTS

ACCESS CLINICAL STUDIES

MARKET OPPORTUNITIES

Weight Management

Xanthigen supports healthy body weight through a dual mode of action – affecting both energy expenditures and fat reserves.

APPLICATIONS

SOFT GELS

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ORIGIN STORY & INSIGHTS

Weight Management from the Opposite Edits of the Earth

Xanthigen is a synergistic combination of two plant-based compounds derived from brown seaweed and pomegranate oil.

Brown Seaweed from the Pacific Northwest

Brown seaweed extract (BSE) is derived from Undaria pinnatifida,– otherwise known as wakame – is a brown seaweed containing the xanthophyll fucoxanthin, which has been shown to help burn fatty tissue.

Pomegranate from the Mediterranean

Originating from the Himalayas in northern India, Punica granatum (pomegranate) is cultivated throughout the Mediterranean region. Pomegranate seed oil is rich in antioxidants and polyphenols and is known to lower cholesterol.

The #1 Weight Loss Ingredient in Korea

For nearly a decade, Xanthigen has been featured in dozes of weight management SKUs in the South Korean market. Today, Xanthigen is the top-selling weight loss ingredient in this market.

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Weight Management Finalist in 2018 for NutraIngredients Asia

Based on its body of science and its global reputation – particularly in South Korea – Xanthigen was named as a Finalist in the Weight Management category of the NutraIngredients Asia Awards in 2018.

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ID Assessment and Quality Assurance

PLT innovation partner Nektium is a global leader in sourcing and processing botanicals and other natural materials. Raw material sources are selected for sustainability and the ability to control cultivation, harvesting, collection and delivery to its processing facility.

As a part of its ingredient identity and quality control process, every batch of material undergoes multiple identity tests, including macroscopic and sensorial analysis, the development of chromatographic profiles and independent DNA barcode analysis to ensure the authenticity of the raw material.

At its state-of-the-art facility in the Canary Islands, Nektium specializes in extraction, concentration and drying processes. Most ingredients are standardized to provide precise levels of bioactive compounds. The resulting HPLC ‘fingerprint’ is consistent from batch to batch and matches the goals set for the ingredient.

Nektium’s Good Manufacturing Practice includes practices and systems that are required to be adapted in botanicals manufacturing, quality control (QC) and quality management systems (QMS).