zümXR® Targeted Release Caffeine

Targeted Release Caffeine for Customized Energy Profiles

Not Less Than 80%

Effective payload

1st

Clinically studied extended-release caffeine

#1

Stated need in pre-workout products

92%

Would pay a premium for multi-phase energy

	Clinically studied pharmacokinetics
	Tightly controlled coating materials
	Pharma modeling techniques
	Tightly controlled dissolution specs
	High physical quality ingredients
	Design custom energy profiles
	Consumer study shows premium purchase preference
	Made in the USA
	Multiple grades available

CERTIFICATIONS

GLUTEN-FREE

NON-GMO

VEGAN

SOLVENT-FREE

A Contemporary Ingredient Made Better by Pharma Science

zümXR Targeted Release Caffeine is a new form of modified release caffeine developed for food, beverage and supplement products. It is available in Delayed Release and Extended-Release forms. Caffeine sources include both synthetic anhydrous and natural green coffee.

Caffeine

Many of us depend on regular doses of 1,3,7 trimethylxanthine, the chemical name for the white powder known as caffeine.

zumxr-ingredient-circle

Moving Faster

It helps wake us up, keep us alert and get us moving at a faster pace.

Rhodiola rosea

Rhodiola rosea is a plant native to remote Arctic climates in Asia, Europe and North America.

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Exciting Phytochemistry

The root of the plant contains around 140 chemical compounds including phenols, rosavin, rosarin, salidroside and more.

Detail 1

Kale chips cold-pressed put a bird on it mumblecore kogi brooklyn farm-to-table blue bottle yuccie authentic kombucha migas. Literally tilde tacos paleo.

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Detail 2

Kale chips cold-pressed put a bird on it mumblecore kogi brooklyn farm-to-table blue bottle yuccie authentic kombucha migas. Literally tilde tacos paleo.

First-ever clinical study on extended release caffeine

To understand the efficacy of the zümXR technology, a pharmacokinetic study (PK) with human participants was developed. In a randomized, double-blind, two-way crossover pharmacokinetic study, with immediate release (anhydrous caffeine) and zümXR Extended Release Caffeine, PK parameters were evaluated.

The primary objective was to compare plasma levels of caffeine between groups after providing participants with equal amounts of caffeine (250 mg). Secondary objectives were to characterize the relative absorption and PK characteristics and to assess the safety profile (vital signs – blood pressure and heart rate) of the Immediate Release Caffeine (IRC) and Extended Release (ERC) forms of caffeine.

Results from this study depict a dramatic increase in caffeine half-life of the zümXR Extended Release Caffeine compared to unencapsulated, immediate release (IR) caffeine.

Clinical Study: Pharmacokinetic Study on Extended Release Caffeine

zumxr Pharmacokinetic Study on Extended Release Caffeine chart-1

Results from this study show a dramatic increase in caffeine half-life of the zümXR Extended Release Caffeine compared to unencapsulated, immediate release (IR) caffeineResults from this study show a dramatic increase in caffeine half-life of the zümXR Extended Release Caffeine compared to unencapsulated, immediate release (IR) caffeine

GET THE RESULTS

ACCESS CLINICAL STUDIES

MARKET OPPORTUNITIES

Active/Sports Nutrition

Caffeine is a ‘go to’ ingredient in most pre-workout products. zümXR Targeted Release Caffeine takes energy to the next level.

Cognitive and Mood

zümXR Targeted Release Caffeine is a ‘high tech’ version of the morning cup of coffee – delivering benefits all day.

E-Sports

zümXR Targeted Release Caffeine can help you give gamers the benefits they want longer – without the drawbacks.

Weight Management

Many of today’s top-selling weight management products include caffeine for its thermogenic and appetite suppressant activity.

APPLICATIONS

BEVERAGES

CAPSULES

EFFERVESCENTS

POWDERS

RTDS/SHOTS

SOFT GELS

STICK PACKS

TABLETS

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ORIGIN STORY

The Science Behind Making Caffeine Last Longer and Work Better

Caffeine is a bitter, white crystalline xanthine alkaloid that has an objectionable taste. Initial technologies created to ‘coat’ caffeine – lipids, waxes and water-soluble resins, focused on masking flavor – and were later adapted to modified release applications.

Tableting Technology

Other early modified release caffeine solutions were accomplished using tableting technology which eliminated potential use in powders and beverages. In addition, most lipid or wax based products are not heat stable, nor do they provide a consistent or reliable release profile.

Targeted Release Caffeine

The zümXR approach to Targeted Release Caffeine was developed using pharma modeling techniques for dissolution design, with USP methodologies used to measure performance. It features multi-patented encapsulated micro-bead delivery systems with controlled payload delivery.

Extended-Release Caffeine

zümXR Extended-Release Caffeine was examined in pharmacokinetic study compared with immediate release (anhydrous caffeine). Results showed a dramatic increase in caffeine half-life of the zümXR caffeine compared to conventional caffeine.

Control is the key to precision performance

When it is manufactured, zümXR Targeted Release features high quality, tightly controlled coating materials that are heat stable, which broadens the applications where these ingredients can be used. The flexibility of this technology allows targeted release caffeine solutions to be used in a broad array of applications, including beverage powder premixes, supplements, stick packs, powders, gummies, bars and gels.

Every lot of material manufactured by zümXR is tested prior to shipment to ensure the product meets stringent quality standards, which includes verification of the exact desired release profile. zümXR Targeted Release Caffeine fills an important market need for an experiential ingredient that performs as advertised in energy applications – where to date this performance has been lacking in modified release caffeine.

Two Grades to Support Your Product Development Goals

zümXR Extended Release Caffeine

zümXR Extended Release Caffeine is designed to provide long-term energy without the ‘crash’ associated with many caffeine products. In its specification, it delivers not more than 55% of the total caffeine at 1 hour and not less than 80% at 6 hours.

zümXR Delayed Release Caffeine

zümXR Delayed Release Caffeine delivers not more than 25% at 1 hour and over 80% at 2 hours – for a surge of caffeine at a fixed time interval.

The zümXR Consumer Study

A survey of men who regularly use pre-workout supplement products revealed an exciting fact: targeted release energy – at a relatively small incremental cost – is one of the most effective things you can add to your sports nutrition product to have a dramatic impact on perceived value and purchase preference.

The survey was conducted by a well-known third-party consumer market research company – of 161 men from ages 20-40 who regularly use pre-workout products. They were asked about their workout habits and about their caffeine/energy pain points and preferences. Consumers definitely want longer lasting energy from their pre-workout products. The survey showed that more people chose the targeted release caffeine pre-workout product – and were 2.5 times more likely to choose it than the product they currently use. That willingness to switch shows an opportunity for you to gain – or defend – market share. For more information on this survey, click here.

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zümXR® Targeted Release Caffeine Product Sheet

March 22, 2020

Behind every ingredient solution is an even better story, download the product sheet to learn more.

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zümXR® Targeted Release Caffeine Infographic

March 22, 2020

How consumers respond to the idea of targeted energy in the sports nutrition market.

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Nano Pharmaceuticals Labs Partners with PLT Health Solutions to Expand its zümXR Targeted Release Ingredients Globally

April 19, 2023

PLT Health Solutions, Inc. announced that it has partnered with Nano Pharmaceuticals Labs, LLC (Denver, CO) to market its portfolio of targeted release ingredients on a global basis.

Press Releases

A comparative pharmacokinetic evaluation of caffeine in two different delivery vehicles in healthy adults

Clinical Research

GET THE RESULTS

zümXR Formulator’s Forum

July 20, 2023

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zümXR Sports Energy Infographic

November 20, 2024

With zümXR targeted release caffeine your are in control of the energy experience.

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zümXR Energy Infographic

November 20, 2024

With zümXR targeted release caffeine your are in control of the energy experience.

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Cognitive Support: The New Frontier of Well-Being

February 23, 2023

Explore the latest in cognitive support for well-being with PLT's ingredient platform. In this webinar, you'll discover the science behind cognitive ingredients and how to incorporate them into formulations.

On-Demand Webinars

Our international network, passionate team of experts and extensive industry knowledge is what sets us apart.

zümXR® Targeted Release Caffeine

OVERVIEW

With zümXR® Targeted Release Caffeine ingredients, you can create unlimited, unique energy profiles – by combining immediate release, delayed release and extended-release ingredients.

Not Less Than 80%

1st

#1

92%

FEATURES & BENEFITS

Clinically studied pharmacokinetics

Tightly controlled coating materials

Pharma modeling techniques

Tightly controlled dissolution specs

High physical quality ingredients

Design custom energy profiles

Consumer study shows premium purchase preference

Made in the USA

Multiple grades available

CERTIFICATIONS

A Contemporary Ingredient Made Better by Pharma Science

Caffeine

Moving Faster

Rhodiola rosea

Exciting Phytochemistry

Detail 1

Detail 2

RESEARCH

First-ever clinical study on extended release caffeine

CLINICAL HIGHLIGHTS

Clinical Study: Pharmacokinetic Study on Extended Release Caffeine

MARKET OPPORTUNITIES

Active/Sports Nutrition

Cognitive and Mood

E-Sports

Weight Management

APPLICATIONS

ORIGIN STORY

The Science Behind Making Caffeine Last Longer and Work Better

Tableting Technology

Targeted Release Caffeine

Extended-Release Caffeine

QUALITY

Control is the key to precision performance

INSIGHTS

Two Grades to Support Your Product Development Goals

zümXR Extended Release Caffeine

zümXR Delayed Release Caffeine

The zümXR Consumer Study

“Consumers want longer lasting energy. A PLT consumer survey showed that more people chose a targeted release caffeine pre-workout product – and were 2.5 times more likely to choose it than the product they currently use.”

RESOURCES

Redefine Your Energy Products with PLT